OBJECTIVE:We aimed to evaluate the effect of slow-release (SR) Fampridine on multiple outcome measures reflecting different domains, and to compare the responsiveness of the Six Spot Step Test (SSST) and the Timed 25 Foot Walk (T25FW).
METHODS:For this study 108 participants were included. On day 0 they were tested with the T25FW, the SSST, the 9-Hole Peg Test (9-HPT), the 5 Times Sit-To-Stand test (5-STS) and the Symbol Digit Modalities Test (SDMT). Four weeks of treatment with SR Fampridine 10 mg BID was commenced. Participants were tested again after 26-28 days of treatment.
RESULTS:Mean changes observed were: SSST -3.4±6.4s (Faster) (p<0.001), T25FW -1.2±3.7s (p<0.001)(Faster) , 9-HPT -1.2±6.0s (p<0.001)(Faster) , 5- STS -3.4±7.2s (p<0.001) (Faster) and SDMT 1.4±4.8 a.u. (p=0.003) (better). Change on the SSST differed significantly from T25FW (SSST 17.0±19.6% vs. T25FW 11.2±17.1%, p=0.0013). Some 48.6% were found to have a meaningful change on the SSST compared with 25.7% on the T25FW. The response to treatment with SR Fampridine did not correlate with age, sex, Expanded Disability Status Scale and disease duration.